Ending the HIV Epidemic plans have been sweeping across the nation for several years and many of these plans started as grassroots movements to make HIV prevention and treatment plans that reflected community priorities. Last year, the federal government announced they were committing to creating ending the HIV epidemic plans for America. To successfully end HIV in Tennessee, we must also address the overlapping epidemics heavily impacting our communities. The Tennessee Department of Health and Tennessee Department of Mental Health and Substance Abuse Services are supporting the creation of  an “End the Syndemic (ETS)” plan, which will be an integrated prevention and treatment blueprint for Tennessee, inclusive of HIV, sexually transmitted infections, substance use disorder, and viral hepatitis. From March 2020 through the end of 2021, the End the Syndemic plan will be developed through meaningful community engagement with local stakeholders impacted by and/or working to address one or more of the overlapping epidemics.